Bonnie Ky, MD, MSCE, FACC, Ronald M. Witteles, MD, Marielle Scherrer-Crosbie, MD, PhD, and W. Greg Hundley, MD discuss the topic of statin cardioprotection, the STOP-CA trial presented at ACC.23, the PREVENT study published in NEJM Evidence, and the key takeaways of these two studies. Future directions and goals for the field are also discussed.