In this episode, Jian'an Wang discusses a pivotal study on the long-term outcomes of left atrial appendage occlusion (LAAO) for stroke prevention in patients with non-valvular atrial fibrillation, analyzing data from over 3,000 patients across China. The findings reveal that combining LAAO with ablation significantly reduces ischemic events, highlighting the importance of tailored procedural strategies and anticoagulation regimens to enhance patient care.

In this episode, Jian'an Wang examines a study on the predictive power of integrating fractional flow reserve computed tomography (FFR CT) and its local gradient in assessing future coronary events in patients. The findings suggest that this combined approach significantly enhances risk prediction, offering valuable insights for more informed clinical decision-making in managing coronary artery disease.

In this episode, Jian'an Wang explores the promising role of traditional Chinese medicine (TCM) in managing cardiovascular diseases, emphasizing the law being theory's focus on circulation regulation. The review highlights TCM formulas that enhance metabolic health and microcirculation, suggesting that integrating TCM with conventional treatments could improve patient outcomes and expand therapeutic options in cardiovascular care.

In this episode, Jian'an Wang discusses a study investigating the relationship between elevated serum lipoprotein A (LPA) levels and the risk of severe degenerative aortic stenosis in a cohort of 742 patients. The findings reveal a significant association, particularly with LPA levels exceeding 100 mg/dL, highlighting LPA's potential as a therapeutic target and underscoring the need for further research into therapies aimed at lowering LPA levels.

In this episode, Jian'an Wang examines a nationwide study on acute autoimmune pericarditis (AAP) in Japan, highlighting its prevalence, diagnostic challenges, and in-hospital outcomes compared to acute idiopathic pericarditis (AIP). The findings reveal that while mortality rates are similar, AAP is linked to a higher incidence of cardiac tamponade, underscoring the need for accurate diagnosis to optimize patient care.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published scoping review on prospective human validation of artificial intelligence interventions in cardiology.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on trends in glucagon-like peptide-1 receptor agonist social media posts using AI.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on an association between social isolation with age-gap determined by AI-enabled electrocardiography.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on improving cardiovascular disease prediction with machine learning using UK Biobank mental health data.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on an impact of case and control selection on training artificial intelligence screening of cardiac amyloidosis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper about a clinical cohort study using an artificial intelligence algorithm for detection of severe aortic stenosis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on machine learning prediction for prognosis of patients with aortic stenosis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on coronary artery stenosis and high-risk plaque assessed with an unsupervised fully automated deep learning technique.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on machine-learning for phenotyping and prognostication of myocardial infarction and injury in suspected acute coronary syndrome.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on a 1-year randomized controlled trial of a digital twin in managing hypertension among people with Type 2 diabetes.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper about implications of diagnosis through a machine learning algorithm on management of people with familial hypercholesterolemia.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on mortality risk stratification utilizing artificial intelligence electrocardiogram for hyperkalemia in cardiac ICU Patients.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on Identifing patients with normal ejection fraction at risk of worse outcomes using AI–enhanced electrocardiography.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on automated assessment of right atrial pressure from ultrasound videos using machine learning.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on echocardiogram vector embeddings via R3D transformer for the advancement of automated echocardiography.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on AI prediction of cardiovascular events using opportunistic epicardial adipose tissue assessments from computed tomography calcium score.

Ron Witteles, MD, and and Andrew Nguyen, MD, discuss the study design and findings of HELIOS-B, and clinical impact of vutrisiran in transthyretin amyloid cardiomyopathy.

Pratik Doshi, MD, MS, and Aakriti Gupta MD, MSc, dive into the latest updates and key takeaways from this month's European Society of Cardiology (ESC) Congress. This expert analysis explores groundbreaking research, clinical advances, and the emerging trends that are poised to influence cardiovascular medicine in the years to come.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on for implementing innovative family communication and cascade testing strategies for familial hypercholesterolemia

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on neutrophil extracellular traps in ST-Segment elevation myocardial infarction.