In this episode, Jian'an Wang discusses a study investigating the relationship between elevated serum lipoprotein A (LPA) levels and the risk of severe degenerative aortic stenosis in a cohort of 742 patients. The findings reveal a significant association, particularly with LPA levels exceeding 100 mg/dL, highlighting LPA's potential as a therapeutic target and underscoring the need for further research into therapies aimed at lowering LPA levels.