In this episode of the JACC: Asia podcast, Cheol Hyun Lee explores the prognostic impact of patient-prosthesis mismatch (PPM) following transcatheter aortic valve replacement (TAVR) in Asian patients, who tend to have smaller annular sizes compared to Western populations. The study highlights that while severe PPM occurs in only 1.3% of patients, it is significantly linked to a higher risk of heart failure hospitalization, underscoring the need for personalized treatment approaches in Asia to reduce the risk of severe PPM.