In this episode, Dr. Abdullah Al-Abcha and Dr. Shao-Liang Chen, discusses the groundbreaking findings of the Ivis ACS trial, which compares Ivis-guided versus angiography-guided PCI in diabetic patients with acute coronary syndrome. The results reveal a significant reduction in target vessel failure for Ivis-guided procedures, underscoring the need for updated guidelines and future research to improve outcomes in this high-risk population.