How does high physical activity level impact risk of incident carotid plaque components? Dr. Luosiyuan Zuo reported his research on how high physical activity level impacted the risk at ESC Congress 2024 and further discussed this topic based on the abstract for the ESC Congress 2024. Moderated by Dr. Zhangling Chen.

This issue features the first ever JACC: CardioOncology Expert Panel, providing consensus guidance and identifying the gaps in evidence in the cardiovascular care of our cancer patients. This is the first of a 3-part series focused on advancing evidence-based cardiovascular care prior to, during and after cancer therapy. Additionally, in this issue, we feature a number of high-impact state of the reviews, original research manuscripts and viewpoints.

In this episode of the JACC: CardioOncology Podcast, Antonio Cannata discusses the PROACT clinical trial, which investigated the effectiveness of enalapril in preventing cardiac damage in breast cancer and lymphoma patients undergoing anthracycline therapy. Despite neutral results, the conversation delves into the challenges of defining myocardial injury and emphasizes the need for improved risk stratification and innovative trial designs in future research.

In this episode, Brian Halliday discusses a Korean study examining the outcomes of patients with cancer therapeutics-related cardiac dysfunction after withdrawing cardioprotective therapy. He highlights that while patients with an ejection fraction between 45 and 55% fared similarly regardless of therapy continuation, those with an ejection fraction below 45% experienced worse outcomes when they withdrew treatment, underscoring the need for further randomized trials to refine therapeutic approaches.

In this episode, Dr. Sonia Shah explores a study from Australian researchers that evaluates the effectiveness of a polygenic risk score in predicting heart failure among cancer survivors. While the score enhanced prediction compared to age and sex alone, it did not significantly outperform existing modifiable risk factors, highlighting the need for more comprehensive models that account for unique risks faced by cancer patients.

In this episode, Brian Joyce discusses a groundbreaking study that examines the link between DNA methylation and the incidence of cardiovascular disease and cancer across three major cohorts. The research identifies shared epigenetic signatures associated with both diseases, highlighting the need for further investigation into their functional implications and potential clinical applications in diverse populations.

In this episode, Dr. Tochi Okwuosa discusses a pivotal study examining the association between the Life Essential 8 cardiovascular health score and the incidence of cardiovascular disease in women with breast cancer. The research, which followed over 7,000 participants, found that higher scores correlated with significantly lower rates of cardiovascular events, underscoring the importance of cardiovascular health even in cancer patients and highlighting the need for future studies in more diverse populations.

In this episode, Dr. Josh Mitchell reviews a significant study that explores the links between physical health markers, such as waist circumference and hand grip strength, and cardiovascular outcomes in men with prostate cancer undergoing androgen deprivation therapy. The findings indicate that increased waist circumference and decreased grip strength are associated with higher cardiovascular event risks, highlighting the need for targeted interventions like exercise in these patients and emphasizing the importance of further research in diverse populations.

In this episode, Efstratios Koutroumpakis discusses a critical study on autonomic dysfunction among adult survivors of childhood cancer, highlighting its prevalence and functional significance compared to community controls. The research underscores the complex etiologies of autonomic dysfunction linked to cancer treatments and stresses the importance of early detection and standardized testing to improve cardiovascular health and quality of life in this growing survivor population.

Emile Daoud, MD, Associate Editor of JACC: Clinical Electrophysiology discusses a recently published original research

Emile Daoud, MD, Associate Editor of JACC: Clinical Electrophysiology discusses a recently published original research paper on Stereotactic Radioablation for Septal Ventricular Tachycardias

Emile Daoud, MD, Associate Editor of JACC: Clinical Electrophysiology discusses a recently published original research paper on overcoming lead penetration failure in left bundle branch pacing.

JACC: Heart Failure Social Media Editor Giorgia Benzoni, MD, discusses a recently published Leading Edge Commentary comparing the pathophysiological differences between ATTR and AL cardiac amyloidosis and implications for therapy.

Anju Bhardwaj, MD, social media editor of JACC: Heart Failure, discusses a recently published original research paper assessing the safety and efficacy of continuing sacubitril/valsartan in patients with deterioration of kidney function below an eGFR of 30 mL/min/1.73 m2.

In this episode of the JACC: Asia podcast, host Jian'an Wang summarizes the October 2024 issue, featuring five original research articles that explore crucial topics in cardiovascular health, including the risks of acute autoimmune hepatitis and advancements in telemedicine for managing atrial fibrillation in rural China. Additionally, a state-of-the-art review highlights the potential of traditional Chinese medicine in treating cardiovascular diseases, underscoring the importance of innovative approaches in enhancing patient care.

In this episode, Dr. Danilo Malandrino discusses a pivotal study on acute autoimmune pericarditis, revealing critical differences in hospital outcomes between autoimmune and idiopathic cases based on a comprehensive Japanese registry. The findings underscore the need for careful evaluation of underlying autoimmune diseases in patients with pericarditis, highlighting distinct prognoses and the importance of tailored treatment strategies.

In this episode, Jian'an Wang explores the Miracle AF trial, a groundbreaking telemedicine initiative aimed at improving care for elderly patients with atrial fibrillation in rural China. By integrating village doctors into a structured care model, the study seeks to enhance clinical outcomes and highlight the transformative potential of telehealth in underserved communities.

In this episode, Professor Yong-Joon Lee discusses a significant study on the one-year clinical outcomes of left atrial appendage occlusion (LAAO) using the Watchman device in older patients with non-valvular atrial fibrillation. The findings highlight the procedure's safety and efficacy, revealing that combined LAAO and ablation significantly reduce the risk of thromboembolic events, while also addressing gaps between clinical guidelines and real-world practices.

In this episode, Jian'an Wang discusses a pivotal study on the long-term outcomes of left atrial appendage occlusion (LAAO) for stroke prevention in patients with non-valvular atrial fibrillation, analyzing data from over 3,000 patients across China. The findings reveal that combining LAAO with ablation significantly reduces ischemic events, highlighting the importance of tailored procedural strategies and anticoagulation regimens to enhance patient care.

In this episode, Jian'an Wang examines a study on the predictive power of integrating fractional flow reserve computed tomography (FFR CT) and its local gradient in assessing future coronary events in patients. The findings suggest that this combined approach significantly enhances risk prediction, offering valuable insights for more informed clinical decision-making in managing coronary artery disease.

In this episode, Jian'an Wang explores the promising role of traditional Chinese medicine (TCM) in managing cardiovascular diseases, emphasizing the law being theory's focus on circulation regulation. The review highlights TCM formulas that enhance metabolic health and microcirculation, suggesting that integrating TCM with conventional treatments could improve patient outcomes and expand therapeutic options in cardiovascular care.

In this episode, Jian'an Wang discusses a study investigating the relationship between elevated serum lipoprotein A (LPA) levels and the risk of severe degenerative aortic stenosis in a cohort of 742 patients. The findings reveal a significant association, particularly with LPA levels exceeding 100 mg/dL, highlighting LPA's potential as a therapeutic target and underscoring the need for further research into therapies aimed at lowering LPA levels.

In this episode, Jian'an Wang examines a nationwide study on acute autoimmune pericarditis (AAP) in Japan, highlighting its prevalence, diagnostic challenges, and in-hospital outcomes compared to acute idiopathic pericarditis (AIP). The findings reveal that while mortality rates are similar, AAP is linked to a higher incidence of cardiac tamponade, underscoring the need for accurate diagnosis to optimize patient care.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published scoping review on prospective human validation of artificial intelligence interventions in cardiology.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on trends in glucagon-like peptide-1 receptor agonist social media posts using AI.