Commentary by Dr. Katsuhiko Imai.

Commentary by Dr. Satoshi Shizuta.

Commentary by Dr. Deep Chandh Raja.

Commentary by Dr. Leandra Serio.

Deputy Editor Kenneth Ellenbogen presents an in‑depth discussion of the study “Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model.” In this episode, Dr. Ellenbogen walks listeners through how prolonged atrioventricular conduction can drive structural and electrical remodeling in the atria, leading to fibrosis and increased susceptibility to atrial fibrillation. He highlights the significance of these findings for understanding AF pathophysiology and considers how this preclinical model may inform future prevention and treatment strategies.

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel pulsed field ablation–based endocardial strategy for ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy. The paper presents an early consecutive experience demonstrating the feasibility, acute effectiveness, and safety of PFA for VT without the need for epicardial access. Dr. Marchlinski highlights the clinical implications of this approach and how tissue-selective, nonthermal energy may expand treatment options for this challenging patient population.

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance regarding the safety of aortic cusp ablation, demonstrating that clinically significant aortic regurgitation is rare and infrequently progressive. Dr. Marchlinski highlights the key findings, procedural considerations, and implications for everyday practice in ventricular arrhythmia ablation.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Remote Management of Patients With Heart Failure in Medically Underserved Areas.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Cardiovascular-Kidney-Metabolic Syndrome and Life Expectancy in U.S. Adults.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on 10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry.

Dr. Michel G. Khouri reviews a landmark study examining patients with AL amyloidosis who achieved a complete cardiac biomarker response, highlighting profound improvements in cardiac structure, function, and long-term survival that rival the general population. The discussion underscores the transformative impact of early diagnosis and modern plasma cell–directed therapies, while reminding clinicians that ongoing multidisciplinary cardiac care remains essential even after sustained cardiac remission.

Dr. Qun Shao discusses two multicenter studies evaluating cardiovascular adverse events associated with bispecific T‑cell engager therapies. Drawing on data from over 700 patients, the episode highlights the incidence, predictors, and clinical impact of cardiovascular complications, emphasizing the importance of baseline risk assessment, targeted monitoring, and multidisciplinary management as use of these therapies continues to expand.

Research fellow, Adrian Chen, discusses a multicenter study evaluating myocardial PD‑L1 expression as a prognostic biomarker in immune checkpoint inhibitor–associated myocarditis. The conversation highlights how elevated myocardial PD‑L1 identifies patients at markedly higher risk for early adverse cardiac events and explores its potential role in improving risk stratification and guiding earlier, more aggressive therapy in this high‑risk population.

Dr. Ky's full issue summary.

Commentary by Dr. Elvin Kedhi.

At ACC.26, Dr. Tharshini Ramalingam speaks with JACC: CardioOncology Editor-in-Chief Dr. Bonnie Ky about the rapid evolution of cardio-oncology, the field’s most urgent priorities, and the need for stronger evidence, risk prediction, cardioprotective strategies, and global implementation. Dr. Ky also shares practical advice for early-career investigators on mentorship, resilience, and what makes a manuscript impactful, rigorous, and truly additive to the field.

In this ACC.26 interview, Dr. Tharshini Ramalingam speaks with Dr. Eric Yang of UCLA about a rare and sobering case presented at ACC.26 of immune checkpoint inhibitor myocarditis with predominant right ventricular failure and cardiogenic shock. Their discussion highlights the diagnostic complexity of atypical myocarditis, the importance of recognizing unusual presentations, and the need for better screening, imaging, and phenotyping strategies in cardio-oncology care and research.

Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Charles Davidson, discuss a recently published original research paper studying the transcatheter tricuspid valve intervention risk scores.

Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Volter Rudolph, discuss a recently published original research paper examining the frequency and outcomes of acute hemodynamic instability following tricuspid interventions.

In this episode of JACC: Clinical Electrophysiology, Deputy Editor Dr. Kenneth Ellenbogen discusses His-Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy: Long-term follow-up from the His-alternative I Trial.