Narjust Florez, MD, Shruti Patel, MD, and Giselle Alexandra Suero-Abreu, MD, PhD, MSc discuss the impact of structural barriers and social determinants of health on limiting access to cardio-oncology care, describe strategies for ensuring equitable representation of underserved patients in clinical trials, and consider changes needed at institutional and policy levels to reduce disparities in access to care. Moderated by Sarah Waliany, MD, MS.